I actually have been using Zend Studio for awhile. I use it for the "intellisense" or whatever ZS calls it ;-) especially for my own classes, makes it nice to use my own "widgets" when I'm coding. The remote debugging feature is cool I'm sure (just a little squeamish about firing it up on my company's production server if ya know what I mean.)
There are a few annoying traits though. For example, I hate the "explorer" window (there I go again with the windows terminology) that seems to lag a bit on the remote end but more especially has this "tease" effect of flickering like you're there only to see your old menu before the drill-downed menu pops up (hard to explain.) I also hate the search and replace. Until it's refined better I would not recommend paying the $300! they're asking (or whatever is is.)
I'll have to checkout Nusphere.
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